Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
CNS Neurosci Ther. 2019 Oct;25(10):1113-1125. doi: 10.1111/cns.13226. Epub 2019 Oct 2.
The predilection site of intracerebral hemorrhage (ICH) is in the basal ganglia, which is rich in white matter (WM) fiber bundles, such as cerebrospinal tract in the internal capsule. ICH induced damage to this area can easily lead to severe neurological dysfunction and affects the prognosis and quality of life of patients. At present, the pathophysiological mechanisms of white matter injury (WMI) after ICH have attracted researchers' attention, but studies on the repair and recovery mechanisms and therapy strategies remain rare. In this review, we mainly summarized the WM recovery and treatment strategies after ICH by updating the WMI-related content by reviewing the latest researches and proposing the bottleneck of the current research.
脑出血(ICH)的好发部位是富含白质(WM)纤维束的基底节区,如内囊中的脑脊髓束。ICH 引起的该区域损伤容易导致严重的神经功能障碍,并影响患者的预后和生活质量。目前,ICH 后白质损伤(WMI)的病理生理机制引起了研究人员的关注,但关于修复和恢复机制及治疗策略的研究仍然很少。在这篇综述中,我们主要通过回顾最新的研究更新了与 WMI 相关的内容,提出了当前研究的瓶颈,总结了 ICH 后 WM 恢复和治疗策略。