Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
Biomed Res Int. 2017;2017:6138424. doi: 10.1155/2017/6138424. Epub 2017 Jun 7.
Hypertensive intracerebral hemorrhage (ICH) could very probably trigger white matter injury in patients. Through the continuous study of white matter injury after hypertensive ICH, we achieve a more profound understanding of the pathophysiological mechanism of its occurrence and development. At the same time, we found a series of drugs and treatment methods for the white matter repair. In the current reality, the research paradigm of white matter injury after hypertensive ICH is relatively obsolete or incomplete, and there are still lots of deficiencies in the research. In the face of the profound changes of stroke research perspective, we believe that the combination of the lenticulostriate artery, nerve nuclei of the hypothalamus-thalamus-basal ganglia, and the white matter fibers located within the capsula interna will be beneficial to the research of white matter injury and repair. This paper has classified and analyzed the study of white matter injury and repair after hypertensive ICH and also rethought the shortcomings of the current research. We hope that it could help researchers further explore and study white matter injury and repair after hypertensive ICH.
高血压性脑出血（ICH）很可能会引发患者的脑白质损伤。通过对高血压性 ICH 后脑白质损伤的不断研究，我们对其发生发展的病理生理机制有了更深刻的认识。同时，我们也找到了一系列针对脑白质修复的药物和治疗方法。在当前现实中，高血压性 ICH 后脑白质损伤的研究范式相对陈旧或不完善，研究中仍存在诸多不足。面对卒中研究视角的深刻变化，我们认为豆纹动脉、下丘脑-丘脑-基底节神经核团以及内囊内白质纤维的结合，将有利于脑白质损伤和修复的研究。本文对高血压性 ICH 后脑白质损伤和修复的研究进行了分类和分析，并重新思考了当前研究的不足。我们希望这有助于研究人员进一步探索和研究高血压性 ICH 后脑白质损伤和修复。
