Nickoloff B J, Wood C
Pediatr Dermatol. 1985 Mar;2(3):201-6. doi: 10.1111/j.1525-1470.1985.tb01053.x.
A study was undertaken in an attempt to identify useful histologic criteria that may allow differentiation between benign idiopathic and mycosis-fungoides-associated follicular mucinosis. We chose young patients because no person under 20 years of age with coexisting follicular mucinosis and mycosis fungoides disease has ever been reported. Our three most important observations in benign juvenile idiopathic follicular mucinosis were as follows: The lymphocytic infiltrate was generally confined to follicular, perifollicular, or perivascular zones with no extension of either normal or atypical mononuclear cells into the epidermis or into papillary/reticular dermis. Within follicular epithelium there were dense collections of lymphocytes with occasionally atypical-appearing nuclei in three of the eight patients, but never as Pautrier microabscesses. There was absence of a significant associated plasma cell or eosinophil-containing inflammatory dermal infiltrate. These findings are in contrast to those of older patients with follicular mucinosis and mycosis fungoides.
开展了一项研究，旨在确定有助于区分良性特发性和蕈样肉芽肿相关的毛囊黏蛋白病的有用组织学标准。我们选择年轻患者，因为从未有过20岁以下同时患有毛囊黏蛋白病和蕈样肉芽肿病的病例报道。我们对良性青少年特发性毛囊黏蛋白病的三项最重要观察结果如下：淋巴细胞浸润通常局限于滤泡、滤泡周围或血管周围区域，正常或非典型单核细胞均未延伸至表皮或乳头/网状真皮。在滤泡上皮内，8例患者中有3例淋巴细胞密集聚集，偶尔可见核形态异常，但从未形成帕托里微脓肿。不存在显著的相关浆细胞或含嗜酸性粒细胞的炎性真皮浸润。这些发现与老年毛囊黏蛋白病和蕈样肉芽肿患者的发现形成对比。
