Chen Fengxia, Zhang Zhicai, Pu Feifei
Department of Medical Oncology, General Hospital of The Yangtze River Shipping, Wuhan, Hubei 430010, P.R. China.
Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.
Oncol Lett. 2019 Oct;18(4):3946-3953. doi: 10.3892/ol.2019.10777. Epub 2019 Aug 22.
Breast cancer is a highly heterogeneous disease consisting of five disease subtypes with distinct histological characteristics, clinical behaviors and prognostic features. Stanniocalcin-1 (STC1) is a secreted glycoprotein hormone that has been demonstrated to regulate calcium and phosphate homeostasis. Mammalian STC1 is expressed in various tissues and is implicated in multiple physiological and pathophysiological processes. In addition, growing evidence has suggested that STC1 serves an oncogenic role in a number of different types of tumor. However, the role of STC1 in breast cancer is complex, considering that some studies have shown that it exerts an oncogenic role, whereas other studies have demonstrated the opposite. The aim of the present review article is to evaluate the currently available data on mammalian STC1 and discuss its potential roles in each subtype of breast cancer.
乳腺癌是一种高度异质性疾病，由五种具有不同组织学特征、临床行为和预后特征的疾病亚型组成。鲽鱼钙蛋白-1（STC1）是一种分泌型糖蛋白激素，已被证明可调节钙和磷的稳态。哺乳动物STC1在多种组织中表达，并参与多种生理和病理生理过程。此外，越来越多的证据表明，STC1在多种不同类型的肿瘤中发挥致癌作用。然而，STC1在乳腺癌中的作用很复杂，因为一些研究表明它发挥致癌作用，而其他研究则得出了相反的结论。本综述文章的目的是评估目前关于哺乳动物STC1的可用数据，并讨论其在每种乳腺癌亚型中的潜在作用。
