[Attempts at production of monoclonal antibodies against human breast tumor cells].

Mouse monoclonal antibodies have been produced by fusion of x 63 Ag 8 . 653 myeloma cells with spleen cells of mice immunized with single cell suspensions of human mammary carcinoma tissue. These antibodies revealed strong differences in binding to cells from malignant and non malignant mammary tissues. The monoclonal antibodies do not react with usual determinants which are present on normal human blood lymphocytes or in human serum.