Division of Biomedical Engineering, Faculty of New Sciences and Technologies, University of Tehran, North Karegar Ave., PO Box 14395-1561, Tehran, Iran.
Division of Biomedical Engineering, Faculty of New Sciences and Technologies, University of Tehran, North Karegar Ave., PO Box 14395-1561, Tehran, Iran.
Tissue Cell. 2019 Oct;60:25-32. doi: 10.1016/j.tice.2019.07.008. Epub 2019 Jul 31.
Due to morbidity and mortality of cardiovascular diseases around the globe, there has been an unmet clinical need for small caliber vascular grafts. Autologous vessels are still the gold standard for small caliber vascular grafts (<6 mm). In an attempt to develop a tissue-engineered vascular graft, several approaches have been pursued. One of the promising techniques is the use of acellular matrices offering a prospect of being able to meet the demand for small caliber vessels. Acellular matrices can ideally preserve the vascular wall complexity, biochemical properties, and bioactivity required for tissue regeneration and function. Various strategies have emerged to increase long term patency of acellular matrices including surface modification and pre-implantation cell seeding. This article reviews the most recent and relevant in vivo studies on acellular small caliber vascular grafts, which provides an outlook toward the preclinical potential of acellular extracellular matrices in vascular tissue engineering.
由于全球心血管疾病的发病率和死亡率，对小口径血管移植物存在未满足的临床需求。自体血管仍然是小口径血管移植物(<6mm)的金标准。为了开发组织工程血管移植物，已经采用了几种方法。一种有前途的技术是使用去细胞基质，有望能够满足小口径血管的需求。去细胞基质可以理想地保留血管壁的复杂性、用于组织再生和功能的生化特性和生物活性。已经出现了各种策略来提高去细胞基质的长期通畅率，包括表面修饰和植入前细胞接种。本文综述了最近关于去细胞小口径血管移植物的体内研究，为去细胞细胞外基质在血管组织工程中的临床前潜力提供了展望。
