John A M, Yadav S
MSC Medical Imaging Technology, Department of Radiodiagnosis, KMC Manglore, Manipal Academy of Higher Education, Karnataka, PIN-575001, India.
MSC Medical Imaging Technology, Department of Medical Imaging Technology, SOAHS, Manipal Academy of Higher Education, Manipal, Karnataka, PIN-576104, India.
Radiography (Lond). 2019 Nov;25(4):346-348. doi: 10.1016/j.radi.2019.04.008. Epub 2019 May 7.
Haemodynamic changes may occur with the rapid intravenous injection of contrast media due to the osmolality of such pharmaceuticals. This study sought to evaluate the effect of bolus administration of intravenous contrast media on blood pressure variation during the Contrast-Enhanced Computed Tomography (CECT) of the abdomen.
The study included 74 patients who underwent abdominal CECT and they were placed in the first group receiving a maximum of 80 ml of iodinated contrast via pressure injector (4 ml/s). A further 74 patients, who underwent non-contrast enhanced abdominal CT, were placed in the second group in which 80 ml of normal saline was administered via the same manner. Patients with hypertension and who were on anti-hypertensive drugs were excluded from the study. Non-invasive blood pressure was monitored before the injection of contrast media/saline and immediately after the portal venous phase for the CECT scan and after 45 s following the administration of normal saline in the non-contrast CT group. Mean systolic and diastolic blood pressures from both groups were compared to find out the effect of contrast bolus administration on blood pressure variation.
Both systolic and diastolic blood pressure increased with the injection of contrast media among CECT scan group. No significant changes in systolic and diastolic blood pressure were found before and after the scan in the non-contrast group.
Bolus administration of 80 ml saline has no effect on blood pressure. The increased blood pressure in contrast enhanced studies was induced by the iodinated contrast media and not by the bolus effect.
由于此类药物的渗透压，快速静脉注射造影剂可能会引起血流动力学变化。本研究旨在评估腹部对比增强计算机断层扫描（CECT）期间静脉推注造影剂对血压变化的影响。
该研究纳入了74例行腹部CECT的患者，他们被分为第一组，通过压力注射器以4ml/s的速度接受最多80ml的碘化造影剂。另外74例行非增强腹部CT的患者被分为第二组，以相同方式给予80ml生理盐水。患有高血压且正在服用抗高血压药物的患者被排除在研究之外。在注射造影剂/生理盐水之前、CECT扫描门静脉期结束后立即以及非增强CT组注射生理盐水45秒后监测无创血压。比较两组的平均收缩压和舒张压，以了解造影剂推注对血压变化的影响。
CECT扫描组中，注射造影剂后收缩压和舒张压均升高。非增强组扫描前后收缩压和舒张压无显著变化。
推注80ml生理盐水对血压无影响。对比增强研究中血压升高是由碘化造影剂引起的，而非推注效应。
