Doğan Volkan, Başaran Özcan, Özlek Bülent, Çelik Oğuzhan, Özlek Eda, Çil Cem, Özdemir Ibrahim Halil, Rencüzoğulları Ibrahim, Özpamuk Karadeniz Fatma, Bekar Lütfü, Aktas Mujdat, Resulzade Mubariz Murat, Kalçık Macit, Aksan Gökhan, Çinier Göksel, Halli Akay Kadriye, Mert Kadir Ugur, Biteker Murat, Kayıkçıoğlu Meral
Department of Cardiology, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey.
Department of Cardiology, Nizip State Hospital, Gaziantep, Turkey.
Turk Kardiyol Dern Ars. 2019 Oct;47(7):599-608. doi: 10.5543/tkda.2019.39293.
Few studies have directly assessed suboptimal management of dyslipidemia in Turkey. This study was conducted to assess patients' understanding and perceptions of high cholesterol as well as physicians' knowledge and awareness of lipid management strategies.
This was a multicenter, observational study (ClinicalTrials.gov identifier: NCT02608645). Consecutive patients admitted to the participating cardiology clinics who were at least 18 years of age and who had been classified in a secondary prevention (SP) group or a high-risk primary prevention (PP) group were enrolled. The study population included 1868 patients from 40 sites in Turkey. Two-thirds (67.5%) of the patients in the SP group had been prescribed a statin, whereas only 30.1% of the PP group patients received statin therapy (p<0.001).
It was determined that 18% of the SP patients and 10.6% of the PP patients had a low-density lipoprotein cholesterol level at the recommended level (p<0.001). A patient survey revealed that almost half of the patients in the PP and in the SP groups were aware that their cholesterol levels were high. Negative information about statin treatment disseminated by media programs was the most common reason (9.4%) given for treatment discontinuation.
Perceptions, knowledge and compliance with the guidelines for PP and SP patients in real-life practice have increased, but it remains far below the desired level. Patients and physicians should have more information about the treatment of hyperlipidemia. More accurate media programming could help to prevent the dissemination of misinformation.
在土耳其，很少有研究直接评估血脂异常的管理欠佳情况。本研究旨在评估患者对高胆固醇的理解和认知，以及医生对血脂管理策略的知识和认识。
这是一项多中心观察性研究（ClinicalTrials.gov标识符：NCT02608645）。纳入了年龄至少18岁、被分类为二级预防（SP）组或高危一级预防（PP）组且连续入住参与研究的心脏病诊所的患者。研究人群包括来自土耳其40个地点的1868名患者。SP组中有三分之二（67.5%）的患者被开具了他汀类药物，而PP组中只有30.1%的患者接受了他汀类药物治疗（p<0.001）。
确定SP组中有18%的患者和PP组中有10.6%的患者的低密度脂蛋白胆固醇水平处于推荐水平（p<0.001）。一项患者调查显示，PP组和SP组中几乎一半的患者意识到自己的胆固醇水平较高。媒体节目传播的关于他汀类药物治疗的负面信息是停药的最常见原因（9.4%）。
在现实生活实践中，PP组和SP组患者对指南的认知、知识和依从性有所提高，但仍远低于期望水平。患者和医生应该获得更多关于高脂血症治疗的信息。更准确的媒体节目有助于防止错误信息的传播。
