外周血白细胞介素-6水平升高的青少年颗粒细胞瘤表现为长期发热和青春期延迟。
Juvenile Granulosa Cell Tumor with Elevated Peripheral Interleukin-6 Level Shows Prolonged Fever and Delayed Puberty.
作者信息
Okuno Keisuke, Yoneda Naohiro, Nishimura Rei, Sano Hitoshi, Ueyama Jun-Ichi, Komatsu Hiroaki, Harada Tasuku, Matsushita Michiko, Kuwamoto Satoshi, Horie Yasushi, Kanzaki Susumu
机构信息
Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan.
Department of Pediatrics, Matsue City Hospital, Matsue 690-8509, Japan.
出版信息
Yonago Acta Med. 2019 Sep 13;62(3):263-267. doi: 10.33160/yam.2019.09.004. eCollection 2019 Sep.
Juvenile granulosa cell tumor (JGCT), classified as a sex cord-stromal tumor, is a rare neoplasm. This is an instructive case report of JGCT accompanied by augmented interleukin (IL)-6 secretion. A 13-year-old girl with prolonged fever and delayed puberty was diagnosed with JGCT of the left ovary based on an imaging study and pathological investigation. Although it was not clear whether IL-6 was secreted from the tumor cells, her serum level of IL-6 was very high. After tumorectomy, the patient's symptoms immediately disappeared, her IL-6 level decreased, and she entered puberty. Therefore, augmented IL-6 secretion production induced by tumors should be considered a potential cause of prolonged fever and/or delayed puberty.
青少年颗粒细胞瘤（JGCT）属于性索间质肿瘤，是一种罕见的肿瘤。这是一篇关于伴有白细胞介素（IL）-6分泌增加的JGCT的指导性病例报告。一名13岁长期发热且青春期延迟的女孩，经影像学检查和病理检查后被诊断为左卵巢JGCT。虽然尚不清楚IL-6是否由肿瘤细胞分泌，但她的血清IL-6水平非常高。肿瘤切除术后，患者症状立即消失，IL-6水平下降，且进入青春期。因此，肿瘤诱导的IL-6分泌增加应被视为长期发热和/或青春期延迟的潜在原因。
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