Geers Andrew L, Fowler Stephanie L, Helfer Suzanne G, Murray Ashley B
Department of Psychology, University of Toledo, Toledo, OH, USA.
National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Pain Rep. 2019 Jun 7;4(3):e693. doi: 10.1097/PR9.0000000000000693. eCollection 2019 May-Jun.
Placebo analgesia often results when a pain reduction treatment message is delivered to a patient or research participant. Little information exists regarding the psychological changes that are immediately triggered by the delivery of a treatment message.
This experiment tested the impact of 3 different analgesic treatment messages on the expectations, feelings, and electrodermal activity of participants anticipating a pain stimulus.
In laboratory sessions, healthy participants (N = 138) were randomly assigned to 1 of 4 conditions in a between-subject design. The design included a no treatment message control condition and 3 treatment message conditions: a standard analgesic message, an analgesic treatment with side-effect message, and a double-blind analgesic message. After the treatment message manipulation, measures were taken of: treatment efficacy expectations, pain experience expectations, pretask anxiety, positive affect, negative affect, and electrodermal activity.
Overall, the dependent measures showed relatively few correlations. Furthermore, across all 3 message conditions, treatment-specific expectations were greatly increased compared with the control condition. Finally, participants in the double-blind message condition displayed elevated negative affect.
All 3 analgesic treatment messages produced a stronger immediate influence on treatment efficacy expectations than on the other dependent measures. Treatment messages can alter negative affect along with expectancies. The low correlations found between dependent measures suggest that different patterns of psychological responses may emerge from analgesic treatment messages depending on contextual factors.
当向患者或研究参与者传递疼痛减轻治疗信息时，常常会产生安慰剂镇痛效果。关于传递治疗信息后立即引发的心理变化，目前所知甚少。
本实验测试了3种不同的镇痛治疗信息对预期疼痛刺激的参与者的期望、感受和皮肤电活动的影响。
在实验室环节中，健康参与者（N = 138）在被试间设计中被随机分配到4种条件中的1种。该设计包括一个无治疗信息的对照条件和3种治疗信息条件：标准镇痛信息、带有副作用信息的镇痛治疗信息和双盲镇痛信息。在进行治疗信息操纵后，对以下方面进行了测量：治疗效果期望、疼痛体验期望、任务前焦虑、积极情绪、消极情绪和皮肤电活动。
总体而言，相关的测量指标显示出相对较少的相关性。此外，与对照条件相比，在所有3种信息条件下，特定治疗的期望都大幅增加。最后，双盲信息条件下的参与者表现出更高的消极情绪。
所有3种镇痛治疗信息对治疗效果期望的即时影响都比对其他相关测量指标的影响更强。治疗信息可以改变消极情绪以及预期。相关测量指标之间发现的低相关性表明，根据情境因素，镇痛治疗信息可能会引发不同的心理反应模式。
