Gültekin Aziz, Yaylalı Olga, Şengöz Tarık, Yüksel Doğangün, Şahin Beyza
Department of Nuclear Medicine.
Department of Biostatistics, Pamukkale University Medical Faculty, Denizli, Turkey.
Nucl Med Commun. 2019 Dec;40(12):1250-1255. doi: 10.1097/MNM.0000000000001097.
The use of Ga-prostate-specific membrane antigen positron emission tomography/computed tomography is spreading due to its clinical benefits. In this study, we aim to determine the intra- and interobserver agreement levels of Ga- prostate-specific membrane antigen-I&T positron emission tomography/computed tomography according to molecular imaging tumor-lymph node-metastases reporting system.
Eighty prostate cancer patients and underwent Ga- prostate-specific membrane antigen positron emission tomography/computed tomography were blindly evaluated twice by four nuclear medicine specialists at intervals of 4 weeks. The evaluations were performed according to molecular imaging tumour-lymph node-metastases (miTNM) classification. We used Cohen's Kappa and Fleiss' Kappa analysis to analyse intra- and interobserver agreements.
When Ga-prostate-specific membrane antigen positron emission tomography/computed tomography findings were evaluated according to miTNM classification, the obtained kappa values were as follows. The intraobserver Cohen's kappa coefficient was found to be 0.79 (substantial agreement), 0.93 (almost perfect agreement), and 0.94 (almost perfect agreement) for miT, miN, and miM, respectively. During interobserver evaluation between the four observers, the kappa coefficient was 0.52 (moderate agreement) for miT, 0.74 (substantial agreement) for miN, and 0.84 (almost perfect agreement) for miM.
There is no research on the intraobserver agreement analysis of Ga-prostate-specific membrane antigen positron emission tomography/computed tomography in the literature. Our findings are the first ones. The intraobserver agreement was almost perfect. Moreover, although Ga-prostate-specific membrane antigen I&T positron emission tomography/computed tomography had moderate interobserver evaluation compliance of the primary tumour, it had excellent interobserver agreement levels in local lymph node metastasis and distant metastasis evaluation.4012501255.
镓前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描因其临床益处而应用日益广泛。在本研究中，我们旨在根据分子影像肿瘤-淋巴结-转移报告系统确定镓前列腺特异性膜抗原-I&T正电子发射断层扫描/计算机断层扫描的观察者内和观察者间一致性水平。
80例接受镓前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描的前列腺癌患者由4名核医学专家每隔4周进行两次盲法评估。评估根据分子影像肿瘤-淋巴结-转移（miTNM）分类进行。我们使用Cohen's Kappa和Fleiss' Kappa分析来分析观察者内和观察者间的一致性。
根据miTNM分类评估镓前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描结果时，获得的kappa值如下。miT、miN和miM的观察者内Cohen's kappa系数分别为0.79（高度一致）、0.93（几乎完全一致）和0.94（几乎完全一致）。在4名观察者之间的观察者间评估中，miT的kappa系数为0.52（中度一致），miN为0.74（高度一致），miM为0.84（几乎完全一致）。
文献中尚无关于镓前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描观察者内一致性分析的研究。我们的发现是首次报道。观察者内一致性几乎完全。此外，尽管镓前列腺特异性膜抗原I&T正电子发射断层扫描/计算机断层扫描对原发肿瘤的观察者间评估符合度中等，但在局部淋巴结转移和远处转移评估方面观察者间一致性水平极佳。4012501255。
