Department of Anatomy, Kasturba Medical College, Mangalore, A Constituent Unit of Manipal Academy of Higher Education, Manipal, Karnataka, India-576104.
Department of Physiology, Kasturba Medical College, Mangalore, A Constituent Unit of Manipal Academy of Higher Education, Manipal, Karnataka, India-576104.
Front Biosci (Elite Ed). 2020 Jan 1;12(1):139-149. doi: 10.2741/E863.
Alzheimer's disease (AD) is a neurodegenerative disorder, which is commonly seen in older individuals. This is characterized by cognitive dysfunction, which leads to dementia. Pharmacological treatments for AD are mainly targeted on its symptoms like memory loss and cognitive impairment. The pathophysiology involved in AD is intra-neuronal accumulation of hyper-phosphorylated tau protein as neurofibrillary tangle and extra cellular beta amyloid plaque deposition, which is due to oxidative stress. Here we review the neuro-protective effects of Resveratrol (RSV) and its treatment efficacy in AD. RSV is a naturally available polyphenolic compound, which has antioxidant, anti-cancerous, anti-inflammatory and anti-aging properties. RSV crosses blood brain barrier and exerts its antioxidant effect by enhancing the anti-oxidant enzymes. RSV is involved in Sirtuin (SIRT1) mediated lifespan extension activity. RSV has reduced glial activation and helped in increasing the hippocampal neurogenesis. RSV was able to decrease the expression of amyloid precursor protein, along with improvement of spatial working memory. Since RSV acts as an antioxidant, it can be safely used as oral drug.
阿尔茨海默病（AD）是一种神经退行性疾病，常见于老年人。其特征是认知功能障碍，导致痴呆。AD 的药物治疗主要针对其症状，如记忆力减退和认知障碍。AD 涉及的病理生理学是神经元内过度磷酸化的 tau 蛋白作为神经纤维缠结和细胞外β淀粉样斑块沉积，这是由于氧化应激。在这里，我们回顾白藜芦醇（RSV）的神经保护作用及其在 AD 中的治疗效果。RSV 是一种天然存在的多酚化合物，具有抗氧化、抗癌、抗炎和抗衰老特性。RSV 能穿过血脑屏障，并通过增强抗氧化酶来发挥其抗氧化作用。RSV 参与 Sirtuin（SIRT1）介导的寿命延长活性。RSV 减少了神经胶质细胞的激活，并有助于增加海马神经发生。RSV 能够降低淀粉样前体蛋白的表达，同时改善空间工作记忆。由于 RSV 是一种抗氧化剂，因此可以安全地用作口服药物。
