Nagahama Institute of Bio-Science and Technology, Nagahama Shiga 526-0829, Japan,
Institute of Basic Biological Sciences, University of Tsukuba, Tsukuba Ibaraki 305-8575, Japan.
Front Biosci (Landmark Ed). 2020 Jan 1;25(1):118-133. doi: 10.2741/4797.
PolyADP-ribosylation is a post-translational modification which is involved in various physiological processes including maintenance of genome stability through DNA repair, regulation of transcription, and development. This process is also involved in pathological events such as cell death. Here, we review the effect of polyADP-ribosylation in signal transduction pathways in system. It is hoped that such an insight paves the way to develop therapeutics for human diseases.
聚 ADP-核糖基化是一种翻译后修饰，参与各种生理过程，包括通过 DNA 修复维持基因组稳定性、转录调控和发育。这个过程也涉及细胞死亡等病理事件。在这里，我们综述了聚 ADP-核糖基化在 系统信号转导通路中的作用。希望这种深入了解能为人类疾病的治疗方法开辟道路。
