心房利钠因子基因的分子研究

Molecular studies of the atrial natriuretic factor gene.

作者信息

Seidman C E, Bloch K D, Zisfein J, Smith J A, Haber E, Homcy C, Duby A D, Choi E, Graham R M, Seidman J G

出版信息

Hypertension. 1985 May-Jun;7(3 Pt 2):I31-4. doi: 10.1161/01.hyp.7.3_pt_2.i31.

DOI:10.1161/01.hyp.7.3_pt_2.i31

Abstract

The molecular biology of human atrial natriuretic factor was studied. A cloned rat cDNA probe was used to analyze tissue for the synthesis of atrial natriuretic factor, and the human gene was identified and sequenced. Nucleotide sequence comparison of human and rodent atrial natriuretic factor genes suggests regions that are critical for regulated expression of this cardiac hormone.

摘要

对人类心房利钠因子的分子生物学进行了研究。使用克隆的大鼠cDNA探针分析组织中的心钠素合成情况，并对人类基因进行了鉴定和测序。人类和啮齿类动物心房利钠因子基因的核苷酸序列比较表明了对这种心脏激素的调节表达至关重要的区域。