Maddox A M, Kahan B D, Tucker S, Kerman R, Jordan R E
J Am Acad Dermatol. 1985 May;12(5 Pt 2):952-6. doi: 10.1016/s0190-9622(85)70121-1.
A 57-year-old woman with mycosis fungoides that had failed to respond to cytotoxic chemotherapy was treated with cyclosporine. Mycosis fungoides and Sézary syndrome are disorders of helper T cells. Cyclosporine is a fungal endecapeptide of novel chemical structure that causes preferential inhibition of T helper cells. Because of this in vitro inhibition of T helper cells, we used cyclosporine to treat a patient who had mycosis fungoides that was refractory to cytotoxic combination chemotherapy. With cyclosporine administered initially as an intravenous infusion and orally after 10 days, there was immediate improvement in the patient's symptoms. This subjective improvement was accompanied by a decrease in her skin infiltration, noted on physical examination and microscopically. Despite continued administration of the cyclosporine, symptoms recurred after 3 1/2 months of therapy.
一名57岁患有蕈样肉芽肿的女性患者，其病情对细胞毒性化疗无反应，遂接受环孢素治疗。蕈样肉芽肿和 Sézary 综合征是辅助性T细胞疾病。环孢素是一种具有新型化学结构的真菌十一肽，可优先抑制辅助性T细胞。由于其在体外对辅助性T细胞的抑制作用，我们使用环孢素治疗一名对细胞毒性联合化疗无效的蕈样肉芽肿患者。最初通过静脉输注给予环孢素，10天后改为口服，患者症状立即改善。体格检查和显微镜检查均显示，这种主观上的改善伴随着皮肤浸润的减少。尽管持续给予环孢素，但治疗3个半月后症状复发。
