Burgio G R
Monatsschr Kinderheilkd. 1985 Apr;133(4):201-6.
Histocompatibility antigens represent the biological basis of individuality. They make men different from one another and represent the essence of "self" which is continuously protected from "non self" by the immune system. Both fecundation and the evolution of pregnancy are favoured by a marked difference in histocompatibility antigens of the mother and father as well as of the mother and the fetus. The biology of pregnancy also find expression in the neonate: different percentages of the subclasses of T lymphocytes and low levels of NK cells and function. On the whole these data and the correlation between histocompatibility antigens and diseases allow life to be interpreted as an immune phenomenon and human individuality as an essentially immunological "biological Ego". Analogies may be found between the "biological" and the "psychological Ego". Many alterations may affect the protective immune network giving rise to primary or acquired immunodeficiencies. They may be expressed slowly and progressively or suddenly. The immune alterations of Down's syndrome and those of infantile AIDS may be taken as heuristic examples in this sense.
组织相容性抗原代表了个体性的生物学基础。它们使人与人彼此不同，并代表了“自我”的本质，而免疫系统会持续保护“自我”免受“非自我”的侵害。受孕和妊娠的发展都得益于母亲与父亲以及母亲与胎儿之间组织相容性抗原的显著差异。妊娠生物学在新生儿身上也有所体现：T淋巴细胞亚类的不同百分比以及自然杀伤细胞水平和功能较低。总体而言，这些数据以及组织相容性抗原与疾病之间的相关性，使得生命可以被解释为一种免疫现象，而人类个体性则被视为一种本质上的免疫“生物自我”。在“生物自我”和“心理自我”之间可以找到相似之处。许多改变可能会影响保护性免疫网络，从而导致原发性或获得性免疫缺陷。它们可能缓慢而渐进地或突然地表现出来。从这个意义上说，唐氏综合征和婴儿艾滋病的免疫改变可以作为启发性的例子。
