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艾日布林诱发的间质性肺炎:病例系列及回顾性队列研究

Eribulin-induced Interstitial Pneumonia: A Case Series and Retrospective Cohort Study.

作者信息

Murakami Manabu, Kanemura Hiroaki, Tomishima Yutaka, Nakano Eriko, Tamura Tomohide

机构信息

Department of Pulmonary Medicine, Thoracic Center, St. Luke's International Hospital, Japan.

Division of Medical Oncology, St. Luke's International Hospital, Japan.

出版信息

Intern Med. 2020 Feb 15;59(4):563-567. doi: 10.2169/internalmedicine.2779-19. Epub 2019 Oct 7.

Abstract

Eribulin is a chemotherapeutic agent used for advanced breast cancer, but there are some reports of eribulin-induced lung injuries. Three of our patients experienced eribulin-related lung injuries. Radiology revealed organizing pneumonia in two cases and diffuse ground-glass shadows indicative of hypersensitivity pneumonitis in the third. A retrospective survey of patients treated with eribulin at our hospital identified no other cases of eribulin-induced lung injuries. Overall, drug-related lung injuries occurred in 2.8% of our eribulin-treated patients, which is similar to the rates reported for other anticancer drugs. The findings from these three cases provide guidance for the safe use of eribulin.

摘要

艾日布林是一种用于治疗晚期乳腺癌的化疗药物,但有一些关于艾日布林引起肺损伤的报道。我们的三名患者出现了与艾日布林相关的肺损伤。放射学检查显示,两例为机化性肺炎,第三例为弥漫性磨玻璃影,提示过敏性肺炎。对我院接受艾日布林治疗的患者进行回顾性调查,未发现其他艾日布林引起肺损伤的病例。总体而言,在我们接受艾日布林治疗的患者中,药物相关肺损伤的发生率为2.8%,这与其他抗癌药物报道的发生率相似。这三例病例的研究结果为艾日布林的安全使用提供了指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d284/7056385/f868ae113a7c/1349-7235-59-0563-g001.jpg

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