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免疫功能正常成年人的致命性人博卡病毒原发性肺炎

Fatal Primary Human Bocavirus Pneumonia in an Immunocompetent Adult.

作者信息

Ishiguro Takashi, Hirota Shuko, Kobayashi Yasuhito, Takano Kenji, Kobayashi Yoichi, Shimizu Yoshihiko, Takayanagi Noboru

机构信息

Departments of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.

Departments of Pathology, Saitama Cardiovascular and Respiratory Center, Japan.

出版信息

Intern Med. 2020 Feb 1;59(3):421-424. doi: 10.2169/internalmedicine.3583-19. Epub 2019 Oct 7.

DOI:10.2169/internalmedicine.3583-19
PMID:31588085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7028423/
Abstract

A 70-year-old woman was admitted to our hospital for dyspnea and a fever of 2 weeks duration. Chest imaging showed bilateral infiltration, and a rapid diagnostic test for influenza virus, Mycoplasma pneumoniae, Streptococcus pneumoniae, and Legionella spp. was negative. She was intubated and mechanically ventilated and underwent bronchoalveolar lavage. Bronchoalveolar lavage fluid yielded no significant pathogens, and the multiplex polymerase chain reaction test was positive only for human bocavirus. Specific antibodies against significant pathogens were not increased in paired sera, so we diagnosed her with primary human bocavirus pneumonia.

摘要

一名70岁女性因呼吸困难和持续2周的发热入住我院。胸部影像学显示双侧浸润,对流感病毒、肺炎支原体、肺炎链球菌和嗜肺军团菌进行的快速诊断检测均为阴性。她接受了气管插管和机械通气,并接受了支气管肺泡灌洗。支气管肺泡灌洗液未检出重要病原体,多重聚合酶链反应检测仅对人博卡病毒呈阳性。配对血清中针对重要病原体的特异性抗体未升高,因此我们诊断她为原发性人博卡病毒肺炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea5/7028423/8a7dfc61b946/1349-7235-59-0421-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea5/7028423/cbe4b6512f1a/1349-7235-59-0421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea5/7028423/6ba5ccf8a8d3/1349-7235-59-0421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea5/7028423/8a7dfc61b946/1349-7235-59-0421-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea5/7028423/cbe4b6512f1a/1349-7235-59-0421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea5/7028423/6ba5ccf8a8d3/1349-7235-59-0421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea5/7028423/8a7dfc61b946/1349-7235-59-0421-g003.jpg

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Human Bocavirus Infection in Adults: Clinical Features and Radiological Findings.成人博卡病毒感染:临床特征和影像学表现。
Korean J Radiol. 2019 Jul;20(7):1226-1235. doi: 10.3348/kjr.2018.0634.
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Human bocaviruses and paediatric infections.人博卡病毒与儿科感染。
Lancet Child Adolesc Health. 2019 Jun;3(6):418-426. doi: 10.1016/S2352-4642(19)30057-4. Epub 2019 Apr 1.
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Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year.全年都能在患有慢性扁桃体炎的儿童中检测到呼吸道病毒。
Int J Pediatr Otorhinolaryngol. 2014 Oct;78(10):1655-61. doi: 10.1016/j.ijporl.2014.07.015. Epub 2014 Jul 21.
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To use or not to use corticosteroids for pneumonia? A clinician's perspective.肺炎治疗中是否使用皮质类固醇?临床医生的观点。
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Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland.儿童呼吸道疾病随访研究中人类博卡病毒 1 感染的相关性,芬兰。
Emerg Infect Dis. 2012 Feb;18(2):264-71. doi: 10.3201/eid1802.111293.
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