Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering , Changzhou University , 1 Gehu Road , Changzhou , Jiangsu 213164 , China.
Department of Chemistry and Chemical Biology , Indiana University Purdue University Indianapolis , Indianapolis , Indiana 46202 , United States.
J Org Chem. 2019 Nov 1;84(21):14045-14052. doi: 10.1021/acs.joc.9b02202. Epub 2019 Oct 17.
Silver-mediated intramolecular α-C(sp)-H bond functionalization of the methylthio group has been established in the presence of Selectfluor as an additive. This novel strategy provides efficient access to various diverse sulfur-based heterocycles with good yields and functional group compatibility. It is noteworthy that the completely novel benzooxathiin-4-imine skeletons were reported for the first time in this study.
在添加了 Selectfluor 作为添加剂的情况下，建立了银介导的甲硫基的分子内α-C(sp)-H 键官能团化。这种新策略为各种不同的基于硫的杂环化合物提供了有效的合成途径，具有良好的产率和官能团兼容性。值得注意的是，在这项研究中首次报道了完全新颖的苯并噁嗪-4-亚胺骨架。
