Daubert J C, Roussel A
Presse Med. 1985 Apr 13;14(15):835-8.
Dual chamber pacemakers have been designed to restore normal atrio-ventricular synchronism and maintain it during exercise. Progressive acceleration of the electrically stimulated heart rate provides "physiological" adaptation of cardiac output. In subjects with a normal heart, the atrial systole plays a relatively minor role (about 20% of the cardiac output at rest), and it is only in rare cases (e.g. pacemaker syndrome) that implanting a dual-chamber pacemaker becomes necessary. However, the atrial systole plays a much greater role in acute or chronic heart diseases, notably in patients with cardiac failure, mitral or tricuspid valve regurgitation or reduced cardiac compliance. Dual chamber pacemakers are more frequently required in such cases to correct or prevent the detrimental effects of normal atrio-ventricular synchronism, among which atrioventricular conduction is the worst tolerated.
双腔起搏器的设计目的是恢复正常的房室同步性,并在运动期间维持这种同步性。电刺激心率的逐渐加快可使心输出量产生“生理性”适应。在心脏正常的受试者中,心房收缩的作用相对较小(静息时约占心输出量的20%),只有在极少数情况下(如起搏器综合征)才需要植入双腔起搏器。然而,心房收缩在急性或慢性心脏病中起着更为重要的作用,尤其是在心力衰竭、二尖瓣或三尖瓣反流或心脏顺应性降低的患者中。在这些情况下,更频繁地需要双腔起搏器来纠正或预防正常房室同步性的有害影响,其中房室传导是最难以耐受的。