人多能干细胞在视网膜和视神经疾病模型中的应用：向体外培养的视网膜迈进。
Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish.
机构信息
Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, Australia; Department of Surgery, The University of Melbourne, Parkville, Australia; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
Department of Surgery, The University of Melbourne, Parkville, Australia; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia.
出版信息
Curr Opin Pharmacol. 2019 Oct;48:114-119. doi: 10.1016/j.coph.2019.09.003. Epub 2019 Oct 4.
Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retina and optic nerve. These cells can then be used to study fundamental biology as well as disease modelling and subsequent screening of potential treatments. Many models of differentiation and modelling have relied on two-dimensional monocultures of specific cell types, which are not representative of the complexity of the human retina and optic nerve. Hence, more complex models of the human retina and optic nerve are required. Three-dimensional organoids and emerging cell culture methods may provide more physiologically relevant models to study developmental biology and pathology of the retina and optic nerve.
人类多能干细胞可分化为特定的、相关的感兴趣的细胞类型，包括视网膜和视神经细胞。这些细胞可用于研究基础生物学以及疾病建模和随后的潜在治疗方法筛选。许多分化和建模模型依赖于特定细胞类型的二维单细胞培养，这不能代表人类视网膜和视神经的复杂性。因此，需要更复杂的人类视网膜和视神经模型。三维类器官和新兴的细胞培养方法可能提供更接近生理的模型，用于研究视网膜和视神经的发育生物学和病理学。
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