甲基丁基甲酮对小鼠肝脏乙醇脱氢酶的抑制作用。
Inhibition of mouse liver alcohol dehydrogenase by methyl N-butyl ketone.
作者信息
Sharkawi M, Elfassy B
出版信息
Toxicol Lett. 1985 May;25(2):185-9. doi: 10.1016/0378-4274(85)90080-3.
PMID:3159129
Abstract
Methyl N-butyl ketone (MNBK) inhibited the activity of mouse liver alcohol dehydrogenase (LADH) in vitro. Ethanol elimination was reduced in MNBK-treated mice as compared to controls. Ethanol-induced induced loss of righting reflex was significantly prolonged in mice pretreated with MNBK.
摘要
甲基正丁基酮（MNBK）在体外抑制小鼠肝脏乙醇脱氢酶（LADH）的活性。与对照组相比，MNBK处理的小鼠体内乙醇消除减少。预先用MNBK处理的小鼠中，乙醇诱导的翻正反射丧失显著延长。
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