Wallis V J, Leuchars E, Chaudhuri M, Davies A J
Immunology. 1979 Sep;38(1):163-71.
Injection of syngeneic, but chromosomally distinguishable, lymph node or spleen cells into adult mice resulted in both T- and B-lymphocyte chimaerism. In spleen-injected mice haematopoietic chimaerism was also established. It appeared that the donor T lymphocytes were added to the host recirculating T-cell pool so that a hyperlymphoid state was produced. The percentage of donor T lymphocytes declined very slowly in normal mice, but remained stable in adult-thymectomized animals. There was no evidence of a homeostatic mechanism involving destruction of excess peripheral T lymphocytes or grossly affecting the flow of T lymphocytes from the thymus into the recirculating T-cell pool. A preliminary model of the T-lymphocyte system is proposed.
将同基因但染色体可区分的淋巴结或脾细胞注射到成年小鼠体内，会导致T淋巴细胞和B淋巴细胞嵌合体的形成。在注射脾细胞的小鼠中，也建立了造血嵌合体。似乎供体T淋巴细胞被添加到宿主循环T细胞池中，从而产生了淋巴细胞增多状态。在正常小鼠中，供体T淋巴细胞的百分比下降非常缓慢，但在成年去胸腺动物中保持稳定。没有证据表明存在一种稳态机制，该机制涉及破坏多余的外周T淋巴细胞或严重影响T淋巴细胞从胸腺流入循环T细胞池的过程。本文提出了一个T淋巴细胞系统的初步模型。
