Sherity Safenaz Y El, Shalaby Shymaa A, Hassan Nayera E, El-Masry Sahar A, El-Banna Rokia A
Biological Anthropology Department, Medical Research Division, National Research Centre, Dokki, Giza, Egypt.
Radiodiagnosis Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Open Access Maced J Med Sci. 2019 Jul 27;7(14):2256-2262. doi: 10.3889/oamjms.2019.640. eCollection 2019 Jul 30.
Post-surgical recurrence of cancer colon occurs in one-third of patients within the first two years, so early detection is important. The assessment of the therapeutic response is important to change protocol strategy. Positron emission tomography/computed tomography PET/CT, a valuable tool gives both metabolic and anatomic information for whole-body regions. Obesity is an important risk factor for colorectal cancer.
To evaluate post-surgical and therapeutic colorectal cancer by PET/CT and study obesity association to its prognosis.
This was a prospective study involved 93 patients with, post-surgical colorectal cancer examined by PET/CT, then follow up after 4-6 months.
There was a statistically significant difference between PET/CT and contrast CT. The sensitivity& the specificity were (96.4%-100% & 92.3%-98.2%) for PET/CT and (84.2%-90.2% & 76.5%-85.4%) for contrast CT respectively. Post-therapeutic follow up showed; progressive course (24.5%), stationary course (26.4%), partial regression (28.3%) and complete regression course (20.8%). Obesity is a risk factor for progression with highly statistically significant to treatment response. Obese patients had a progressive or stationary course of the disease. Also, there was a highly statistically significant association between total abdominal fat & visceral abdominal fat areas with good response of treatment.
PET/CT is the most appropriate imaging technique to detect any recurrence or metastases in post-surgical colorectal cancer with high sensitivity and specificity comparing to CT. Obesity is a predictor risk factor for prognosis of the disease, as generally and abdominally (total & visceral fat) had an association with therapeutic response.
三分之一的结肠癌患者在术后两年内会出现癌症复发，因此早期检测很重要。评估治疗反应对于改变治疗方案策略很重要。正电子发射断层扫描/计算机断层扫描（PET/CT）是一种有价值的工具，可为全身区域提供代谢和解剖信息。肥胖是结直肠癌的一个重要危险因素。
通过PET/CT评估结直肠癌术后及治疗情况，并研究肥胖与其预后的关系。
这是一项前瞻性研究，纳入93例接受PET/CT检查的结直肠癌术后患者，然后在4-6个月后进行随访。
PET/CT与增强CT之间存在统计学显著差异。PET/CT的敏感性和特异性分别为（96.4%-100%和92.3%-98.2%），增强CT的敏感性和特异性分别为（84.2%-90.2%和76.5%-85.4%）。治疗后随访显示：疾病进展（24.5%）、病情稳定（26.4%）、部分缓解（28.3%）和完全缓解（20.8%）。肥胖是疾病进展的危险因素，对治疗反应具有高度统计学意义。肥胖患者疾病呈进展或稳定病程。此外，腹部总脂肪和内脏脂肪面积与良好的治疗反应之间存在高度统计学意义的关联。
与CT相比，PET/CT是检测结直肠癌术后复发或转移的最合适的成像技术，具有高敏感性和特异性。肥胖是该疾病预后的预测危险因素，总体而言，腹部（总脂肪和内脏脂肪）与治疗反应有关。
