Pueschel S M, Pezzullo J C
Am J Dis Child. 1985 Jun;139(6):636-9. doi: 10.1001/archpedi.1985.02140080106045.
We investigated the thyroid function of 151 patients with Down syndrome. Compared with a control group of 89 siblings nearest in age to their brother or sister with Down syndrome, the mean thyroid-stimulating hormone (TSH) value was significantly higher in patients with Down syndrome than in subjects without Down syndrome. However, the mean thyroxine (T4) levels in both groups were nearly the same. In the Down syndrome group there was a trend for TSH values to increase and for T4 values to decrease with advancing age. Of the 151 patients with Down syndrome, ten had both significantly elevated TSH levels (greater than or equal to 9.5 microU/mL) and significantly decreased T4 levels (less than or equal to 5.5 micrograms/dL), 21 had only abnormally high TSH values, seven had only markedly increased T4 levels (greater than or equal to 12.0 micrograms/dL), and three had only significantly decreased T4 levels. The intellectual function of patients with both abnormal TSH and T4 levels was significantly lower (mean IQ, 41.7) than that of Down syndrome patients with only increased TSH values (mean IQ, 53.8) and that of Down syndrome patients with normal thyroid function (mean IQ, 55.3). This study provides further evidence that there is an increased prevalence of thyroid dysfunction in patients with Down syndrome.
我们调查了151例唐氏综合征患者的甲状腺功能。与89名年龄与患有唐氏综合征的兄弟姐妹最接近的对照组相比，唐氏综合征患者的促甲状腺激素（TSH）平均水平显著高于非唐氏综合征患者。然而，两组的平均甲状腺素（T4）水平几乎相同。在唐氏综合征组中，随着年龄增长，TSH值有升高趋势，T4值有下降趋势。在151例唐氏综合征患者中，10例TSH水平显著升高（大于或等于9.5微国际单位/毫升）且T4水平显著降低（小于或等于5.5微克/分升），21例仅有TSH值异常升高，7例仅有T4水平显著升高（大于或等于12.0微克/分升），3例仅有T4水平显著降低。TSH和T4水平均异常的患者的智力功能显著低于仅有TSH值升高的唐氏综合征患者（平均智商，41.7）以及甲状腺功能正常的唐氏综合征患者（平均智商，55.3）。这项研究进一步证明唐氏综合征患者甲状腺功能障碍的患病率增加。
