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系统评价和荟萃分析显示唐氏综合征患者存在特定的微量营养素谱：血钙、硒和锌降低，红细胞铜和锌升高，唾液钙和钠升高。

Systematic review and meta-analysis shows a specific micronutrient profile in people with Down Syndrome: Lower blood calcium, selenium and zinc, higher red blood cell copper and zinc, and higher salivary calcium and sodium.

机构信息

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

MetaCognition Interest Group (MCIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

出版信息

PLoS One. 2017 Apr 19;12(4):e0175437. doi: 10.1371/journal.pone.0175437. eCollection 2017.

DOI:10.1371/journal.pone.0175437
PMID:28422987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5396920/
Abstract

Different metabolic profiles as well as comorbidities are common in people with Down Syndrome (DS). Therefore it is relevant to know whether micronutrient levels in people with DS are also different. This systematic review was designed to review the literature on micronutrient levels in people with DS compared to age and sex-matched controls without DS. We identified sixty nine studies from January 1967 to April 2016 through main electronic medical databases PubMed, Scopus, and Web of knowledge. We carried out meta-analysis of the data on four essential trace elements (Cu, Fe, Se, and Zn), six minerals (Ca, Cl, K, Mg, Na, and P), and five vitamins (vitamin A, B9, B12, D, and E). People with DS showed lower blood levels of Ca (standard mean difference (SMD) = -0.63; 95% confidence interval (CI): -1.16 to -0.09), Se (SMD = -0.99; 95% CI: -1.55 to -0.43), and Zn (SMD = -1.30; 95% CI: -1.75 to -0.84), while red cell levels of Zn (SMD = 1.88; 95% CI: 0.48 to 3.28) and Cu (SMD = 2.77; 95% CI: 1.96 to 3.57) were higher. They had also higher salivary levels of Ca (SMD = 0.85; 95% CI: 0.38 to 1.33) and Na (SMD = 1.04; 95% CI: 0.39 to 1.69). Our findings that micronutrient levels are different in people with DS raise the question whether these differences are related to the different metabolic profiles, the common comorbidities or merely reflect DS.

摘要

唐氏综合征（DS）患者的代谢特征和合并症通常与常人不同。因此，了解 DS 患者的微量营养素水平是否也存在差异是很重要的。本系统综述旨在回顾 1967 年 1 月至 2016 年 4 月期间，有关 DS 患者与非 DS 年龄和性别匹配对照者之间微量营养素水平的文献。我们通过主要电子医学数据库 PubMed、Scopus 和 Web of Knowledge 确定了 69 项研究。我们对四项必需微量元素（铜、铁、硒和锌）、六种矿物质（钙、氯、钾、镁、钠和磷）和五种维生素（维生素 A、B9、B12、D 和 E）的数据进行了荟萃分析。DS 患者的血钙水平较低（标准均数差（SMD）=-0.63；95%置信区间（CI）：-1.16 至-0.09）、血硒水平较低（SMD=-0.99；95%CI：-1.55 至-0.43）和血锌水平较低（SMD=-1.30；95%CI：-1.75 至-0.84），而红细胞锌水平较高（SMD=1.88；95%CI：0.48 至 3.28）和铜水平较高（SMD=2.77；95%CI：1.96 至 3.57）。此外，他们的唾液钙水平较高（SMD=0.85；95%CI：0.38 至 1.33），唾液钠水平较高（SMD=1.04；95%CI：0.39 至 1.69）。我们的研究结果表明，DS 患者的微量营养素水平存在差异，这引发了一个问题，即这些差异是否与不同的代谢特征、常见合并症有关，还是仅仅反映了 DS 本身。

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