Camargo Caio C, Cavassan Nayara R V, Tasca Karen I, Meneguin Silmara, Miot Hélio A, Souza Lenice R
Department of Tropical Diseases, Botucatu Medical School (FMB), Univ Estadual Paulista (UNESP), Botucatu, Brazil.
Department of Nursing, Botucatu Medical School (FMB), Univ Estadual Paulista (UNESP), Botucatu, Brazil.
AIDS Res Hum Retroviruses. 2019 Nov/Dec;35(11-12):1181-1188. doi: 10.1089/aid.2019.0050. Epub 2019 Oct 8.
Sustained adherence to antiretroviral therapy (ART) is critical in the prevention of drug resistance, disease progression, and death. We aimed to assess the level of ART adherence among 112 people living with HIV/AIDS (PLWHA) and to determine associated factors with that. The socioeconomic aspects were evaluated by medical records; the adherence, depression, and coping by specific questionnaires. Although most patients have undetectable viral load (79%) and CD4 T count >500 cells/mm (65%), two-third (66%) of them exhibited a lower adherence, which was directly associated with some signs of depression ( = .006) presented by 65% of them. Some risk factors to presence of depression were female gender ( = .008) and low income ( = .013). In addition, most participants who reported tobacco (33%) and alcohol (29%) consumption had a low or intermediate adherence score. Among the coping strategies, self-control ( = .029), social support ( = .006), problem solving ( = .013), and positive reappraisal ( = .049) led to an improvement in adherence.
持续坚持抗逆转录病毒疗法（ART）对于预防耐药性、疾病进展和死亡至关重要。我们旨在评估112名艾滋病毒/艾滋病感染者（PLWHA）的ART依从性水平，并确定与之相关的因素。通过病历评估社会经济方面；通过特定问卷评估依从性、抑郁和应对情况。尽管大多数患者的病毒载量检测不到（79%）且CD4 T细胞计数>500个细胞/mm³（65%），但其中三分之二（66%）的患者依从性较低，这与65%的患者出现的一些抑郁迹象直接相关（P = 0.006）。抑郁存在的一些风险因素是女性（P = 0.008）和低收入（P = 0.013）。此外，报告吸烟（33%）和饮酒（29%）的大多数参与者依从性得分较低或中等。在应对策略中，自我控制（P = 0.029）、社会支持（P = 0.006）、解决问题（P = 0.013）和积极重新评价（P = 0.049）导致依从性提高。
