Manouvriez P, Cormont F, Bazin H
Ann Inst Pasteur Immunol (1985). 1985 Mar-Apr;136C(2):187-93. doi: 10.1016/s0769-2625(85)80049-0.
Although rnu/rnu homozygous athymic rats are generally considered to be entirely deficient in mature T cells and unable to produce any T-cell-dependent immune response, we were able to induce slight IgE production in some Nude rats after Nippostrongylus brasiliensis infection. This report stresses the importance of taking the greatest care in the use of congenitally athymic rnu/rnu rats, as strong stimulation can, in some individuals, induce reactions which are generally considered to be T-cell-dependent. Hypotheses explaining this phenomenon are suggested.
尽管rnu/rnu纯合无胸腺大鼠通常被认为完全缺乏成熟T细胞，无法产生任何T细胞依赖性免疫反应，但我们在巴西日圆线虫感染后，能够在一些裸鼠中诱导出轻微的IgE产生。本报告强调在使用先天性无胸腺rnu/rnu大鼠时要格外小心的重要性，因为强烈刺激在某些个体中可能会引发通常被认为是T细胞依赖性的反应。文中提出了解释这一现象的假设。
