血塞通注射液与复方制剂治疗急性脑梗死的对比研究：一项荟萃分析

Comparative study of xuesaitong injection and compound injection in the treatment of acute cerebral infarction: a meta-analysis.

作者信息

Duan Xiaojiao, Zhang Dan, Wang Kaihuan, Wu Jiarui, Zhang Xiaomeng, Zhang Bing, Gao Xiaoyan

机构信息

Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

出版信息

J Int Med Res. 2019 Nov;47(11):5375-5388. doi: 10.1177/0300060519879292. Epub 2019 Oct 9.

OBJECTIVE

This study was conducted to systematically evaluate the clinical effectiveness of xuesaitong injection (XST) and compound injection (CSM) in the treatment of acute cerebral infarction (ACI).

METHODS

We searched several databases for randomized controlled trials (RCTs) using XST and CSM for the treatment of ACI. Two researchers independently selected the RCTs and extracted information. The quality of included RCTs was evaluated, and then data were analyzed using RevMan5.3 and STATA 12.0 software.

RESULTS

Twenty-three RCTs that enrolled 2101 participants were included in this study. A meta-analysis showed that XST with routine Western medicine (WM) can achieve a better effect than CSM with WM for the total effective rate ( = 1.22, 95%: 1.18–1.27). In addition, XST combined with WM could improve neurological impairment ( = −4.65, 95%: −7.85 – −1.44) and hemorheological parameters. XST decreased the whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, and plasma fibrinogen.

CONCLUSIONS

For treating ACI, XST combined with WM was more effective than CSM with WM. However, more evidence is needed to support the safety of XST and CSM.

目的

本研究旨在系统评价血塞通注射液（XST）和复方丹参注射液（CSM）治疗急性脑梗死（ACI）的临床疗效。

方法

我们检索了多个数据库，查找使用XST和CSM治疗ACI的随机对照试验（RCT）。两名研究人员独立选择RCT并提取信息。对纳入的RCT质量进行评估，然后使用RevMan5.3和STATA 12.0软件进行数据分析。

结果

本研究纳入了23项随机对照试验，共2101名参与者。荟萃分析表明，血塞通联合西医常规治疗在总有效率方面比复方丹参联合西医常规治疗效果更好（=1.22，95%：1.18–1.27）。此外，血塞通联合西医常规治疗可改善神经功能缺损（=−4.65，95%：−7.85 – −1.44）和血液流变学参数。血塞通降低了全血高切黏度、全血低切黏度、血浆黏度和血浆纤维蛋白原。