一种用于活细胞成像的具有大斯托克斯位移的近红外发射菁染料：酚基团对发射的重大影响。
A NIR-emitting cyanine with large Stokes shifts for live cell imaging: large impact of the phenol group on emission.
机构信息
Department of Chemistry, The University of Akron, Akron, OH 44325, USA.
出版信息
Chem Commun (Camb). 2019 Oct 31;55(88):13223-13226. doi: 10.1039/c9cc06831g.
Abstract
There are a limited number of near-infrared (NIR) emitting (λem = 700-900 nm) molecular probes for imaging applications. A NIR-emitting probe that exhibits emission at ∼800 nm with a large Stokes shift was synthesized and found to exhibit excellent selectivity towards mitochondria for live-cell imaging. The photophysical properties were attributed to an excited "cyanine structure" via intramolecular charge transfer (ICT) involving a phenol group.
摘要
用于成像应用的近红外（NIR）发射（λem = 700-900nm）分子探针数量有限。合成了一种发射波长在∼800nm 左右、Stokes 位移较大的 NIR 发射探针，发现其对活细胞成像具有优异的线粒体选择性。光物理性质归因于通过涉及苯酚基团的分子内电荷转移（ICT）的激发“氰基结构”。
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