Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, Key Laboratory for Green Organic Synthesis and Application of Hunan. Province, College of Chemistry, Xiangtan University, Xiangtan 411105, China.
Org Biomol Chem. 2019 Oct 23;17(41):9163-9168. doi: 10.1039/c9ob01909j.
A 1,3-dipolar cycloaddition of 2-methylquinoline, tert-butyl nitrite (TBN) and alkynes or alkenes for the synthesis of biheteroaryls containing both isoxazoline/isoxazole and quinoline motifs has been developed. In this protocol, TBN serves as a convenient N-O source to convert 2-methylquinoline into intermediate nitrile oxides in situ.
开发了一种通过 2-甲基喹啉、叔丁基硝酮（TBN）和炔烃或烯烃的 1,3-偶极环加成反应来合成同时含有异噁唑啉/异噁唑和喹啉结构的双杂芳基的方法。在该方案中，TBN 作为一种方便的 N-O 源，可将 2-甲基喹啉原位转化为中间腈氧化物。
