School of Chemical Sciences, Mahatma Gandhi University, Priyadarsini Hills P.O., Kottayam, Kerala 686560, India.
Org Biomol Chem. 2019 Oct 23;17(41):9081-9094. doi: 10.1039/c9ob01757g.
The Cadiot-Chodkiewicz reaction offers an elegant strategy for the formation of 1,3-diynes via Cu-catalyzed cross-coupling of alkynyl halides with terminal alkynes in the presence of an amine. Since both unsymmetrical and symmetrical diacetylenes are of considerable interest due to their pharmaceutical, biological and synthetic applications, novel developments in the field of the Cadiot-Chodkiewicz reaction are of great importance. C(sp)-C(sp) coupling plays a central role in the total synthesis of many natural products and polyynes. This review is devoted to the new protocols and applications of the Cadiot-Chodkiewicz cross-coupling reaction that have been developed recently (2015-2019).
Cadiot-Chodkiewicz 反应提供了一种通过铜催化卤代炔烃与末端炔烃在胺存在下的交叉偶联来形成 1,3-二炔的优雅策略。由于由于其在药物、生物和合成应用方面的重要性，不对称和对称的二乙炔都具有相当大的兴趣，因此 Cadiot-Chodkiewicz 反应领域的新发展非常重要。C(sp)-C(sp) 偶联在许多天然产物和多炔的全合成中起着核心作用。这篇综述致力于最近（2015-2019 年）开发的 Cadiot-Chodkiewicz 交叉偶联反应的新协议和应用。
