25-羟维生素 D 浓度与系统性红斑狼疮女性代谢综合征风险的关系。

25-Hydroxyvitamin D concentrations and risk of metabolic syndrome in systemic lupus erythematosus women.

机构信息

Systemic Autoimmune Diseases Research Unit, Hospital de Especialidades, UMAE, Instituto Mexicano del Seguro Social, Puebla, Mexico.

Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, IMSS, Metepec, Puebla, Mexico.

出版信息

Int J Rheum Dis. 2019 Nov;22(11):2067-2072. doi: 10.1111/1756-185X.13715. Epub 2019 Oct 9.

DOI:10.1111/1756-185X.13715

PMID:31596554

Abstract

OBJECTIVE

A protective function of vitamin D in metabolic syndrome (MetS) has been described. The objective of the present study was to examine the relationship between serum 25-hydroxyvitamin D (25(OH)D) concentrations and MetS in non-diabetic systemic lupus erythematosus (SLE) women.

METHODS

Cross-sectional analyses of the relationship between concentrations of 25(OH)D, MetS, and its components were made in 160 non-diabetic SLE women. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III criteria. Serum 25(OH)D was measured by chemiluminescent immunoassay. Serum 25(OH)D concentrations were categorized into quartiles (<16.6, 16.6-21.1, 21.2-26.3, ≥26.4 ng/mL).

RESULTS

A total of 79 (49.3%) SLE women had MetS. Without adjusting for body mass index (BMI) or smoking, the odds of having MetS decreased according to increasing quartiles of 25(OH)D concentrations (P for trend = .03). The odds ratio (OR) of having MetS was 0.4 (95% confidence interval: 0.2-0.9, P = .04) for the highest vs the lowest quartile of 25(OH)D concentrations when adjusted by age. The crude OR of having elevated hypertriglyceridemia decreased according to increasing quartiles of 25(OH)D concentrations (P for trend = .036). However, further adjustments for BMI and smoking removed the inverse association between 25(OH)D concentrations and MetS and its individual components.

CONCLUSION

In non-diabetic SLE women with mild activity, 25(OH)D concentrations are not associated with MetS and its components.

摘要

目的

已有研究描述了维生素 D 在代谢综合征（MetS）中具有保护作用。本研究旨在探讨非糖尿病系统性红斑狼疮（SLE）女性血清 25-羟维生素 D（25（OH）D）浓度与 MetS 之间的关系。

方法

对 160 例非糖尿病 SLE 女性进行了 25（OH）D 浓度与 MetS 及其各组分之间关系的横断面分析。MetS 按照美国国家胆固醇教育计划成人治疗专家组 III 标准定义。血清 25（OH）D 采用化学发光免疫分析法测定。将血清 25（OH）D 浓度分为四组（<16.6、16.6-21.1、21.2-26.3、≥26.4 ng/mL）。

结果

共有 79 例（49.3%）SLE 女性患有 MetS。不调整体重指数（BMI）或吸烟因素，随着 25（OH）D 浓度四分位组的增加，发生 MetS 的几率呈下降趋势（趋势 P 值<.03）。当按年龄进行调整时，25（OH）D 浓度最高四分位数与最低四分位数相比，发生 MetS 的比值比（OR）为 0.4（95%置信区间：0.2-0.9，P =.04）。随着 25（OH）D 浓度四分位组的增加，发生单纯性高甘油三酯血症的 OR 呈下降趋势（趋势 P 值<.036）。然而，进一步调整 BMI 和吸烟因素后，25（OH）D 浓度与 MetS 及其各组分之间的负相关关系消失。