Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
Department of Preventive Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, South Korea.
BMC Geriatr. 2019 Apr 11;19(1):102. doi: 10.1186/s12877-019-1118-y.
Many studies have investigated the association between vitamin D and metabolic syndrome (MetS). However, few studies have investigated the association stratified by sex in the elderly. Therefore, we aimed to evaluate the association between vitamin D, MetS, and its components in Korean elderly men and women.
A total of 987 men and 1949 women aged ≥65 years were recruited through Korean Urban Rural Elderly cohort study. Serum 25-hydroxyvitamin D (25(OH)D) levels were categorized into 4 quartiles and all data were analyzed separately by sex. MetS was defined by the revised criteria of the National Cholesterol Education Program Adult Treatment Panel III.
The participants in the lowest quartile of serum 25(OH)D showed a significant increase in the prevalence of high waist circumference, elevated triglyceride level, and low high-density lipoprotein cholesterol level, as well as MetS itself, in both men and women in a univariate analysis. After adjusting for potential confounders including age, smoking status, drinking status, exercise status, region of residence, seasonality, and parathyroid hormone level, the lowest 25(OH)D quartile group was associated with a higher risk of MetS (odds ratio [OR] 2.25, 95% confidence interval [CI] 1.48-3.43 in men and OR 1.65, 95% CI 1.27-2.16 in women) compared to the highest 25(OH)D quartile group as the reference group. However, no significant association was found between serum 25(OH)D levels and the prevalence of MetS components including hyperglycemia or hypertension in both men and women.
Low 25(OH)D levels were associated with increased odds of MetS; in particular, they were associated with MetS components of high waist circumference, hypertriglyceridemia, and low high-density lipoprotein-cholesterol, after adjusting for age, smoking, alcohol, exercise, region of residency, and seasonality, in men and women over 65 years old.
许多研究调查了维生素 D 与代谢综合征（MetS）之间的关联。然而，很少有研究对老年人进行性别分层的研究。因此，我们旨在评估维生素 D、MetS 及其成分在韩国老年男性和女性中的关系。
通过韩国城市农村老年人队列研究，共招募了 987 名男性和 1949 名 65 岁以上的女性。血清 25-羟维生素 D（25(OH)D）水平分为 4 个四分位数，并分别按性别进行分析。MetS 采用国家胆固醇教育计划成人治疗专家组 III 修订标准定义。
在单变量分析中，男性和女性血清 25(OH)D 最低四分位数组的高腰围、甘油三酯水平升高和高密度脂蛋白胆固醇水平降低以及 MetS 本身的患病率均显著增加。在调整年龄、吸烟状况、饮酒状况、运动状况、居住地区、季节性和甲状旁腺激素水平等潜在混杂因素后，血清 25(OH)D 最低四分位数组与 MetS 风险较高相关（男性比值比 [OR] 2.25，95%置信区间 [CI] 1.48-3.43；女性 OR 1.65，95% CI 1.27-2.16）与最高四分位数组相比，作为参考组。然而，血清 25(OH)D 水平与男性和女性的代谢综合征成分（包括高血糖或高血压）的患病率之间没有显著关联。
低 25(OH)D 水平与 MetS 风险增加相关；尤其是在调整年龄、吸烟、饮酒、运动、居住地区和季节性后，男性和女性 65 岁以上人群的高腰围、高甘油三酯血症和低高密度脂蛋白胆固醇血症与 MetS 成分相关。
