Department of Ophthalmology, University of Tennessee, Memphis, Tennessee.
Flaum Eye Institute, University of Rochester, Rochester, New York.
J Ocul Pharmacol Ther. 2019 Oct;35(8):447-456. doi: 10.1089/jop.2019.0023.
The cornea and its adnexa pose a unique situation of a tightly defined set of requirements for its function. This includes: transparency, perfect built to obtain appropriate refractive power, protective barrier from microbial invaders. Moreso, the cornea also endures extreme external physical conditions (temperature, high and low humidity, winds and alike). All these functions are maintained while preserving a constant state of homogenous wetting. Toward that end the cornea is equipped with an elaborated network of sensory neural network. While enabling the blinking reflex and maintaining the physiological steady state of wetting, this neural network also makes the cornea prone to the discomfort that with or without associated changes seen on medical examination. ISOPT Clinical 2018 discussion touched upon this hypercomplex situation, addressing the role of inflammation and its resulting discomfort in dry eye conditions. The discussion also engulfed the emerging neuropathic pain syndrome that is recently gaining more attention. Another related topic was the utilization of autologous serum tears and its ability to provide amelioration to desperate patients. Finally, the panel discussed the issue of treating corneal infection, including when and how to utilize steroids in the course of therapy. We assume the reader will find interest in this discussion that directly addresses issues seen day in and day out in our busy clinics.
角膜及其附属物构成了一个独特的情况，对其功能有一系列明确的要求。这包括：透明度、完美的构建以获得适当的屈光力、微生物入侵的保护屏障。更重要的是，角膜还承受着极端的外部物理条件（温度、高低湿度、风和类似条件）。所有这些功能都保持在恒定的均匀湿润状态下。为此，角膜配备了一个精心设计的感觉神经网络网络。在实现眨眼反射和维持生理湿润稳态的同时，该神经网络也使角膜容易出现不适，无论是否伴有医疗检查中可见的相关变化。ISOPT Clinical 2018 讨论触及了这种超复杂的情况，探讨了炎症及其导致的干眼症不适的作用。讨论还涵盖了最近越来越受到关注的新兴神经病理性疼痛综合征。另一个相关的主题是利用自体血清泪液及其为绝望患者提供缓解的能力。最后，小组讨论了治疗角膜感染的问题，包括在治疗过程中何时以及如何使用类固醇。我们假设读者会对这个直接解决我们繁忙诊所日常遇到的问题的讨论感兴趣。
