Leung D Y, Young M C, Geha R S
Int Arch Allergy Appl Immunol. 1985;77(1-2):232-4. doi: 10.1159/000233796.
In the present study, Fc epsilon R+ and Fc epsilon R- T cells were isolated from patients with the hyper-IgE syndrome and maintained in long-term cultures with interleukin 2. Supernatants from the Fc epsilon R+ but not from the Fc epsilon R- T cell lines enhanced IgE but not IgG synthesis in B cells derived from patients with allergic rhinitis. There was, however, no induction of IgE synthesis in B cells from nonatopic donors. The IgE-potentiating factors bound to IgE-Sepharose but not to IgG-Sepharose. The target B cells for these IgE binding factors appear to be preactivated IgE-bearing B cells.
在本研究中，从高IgE综合征患者中分离出FcεR⁺和FcεR⁻ T细胞，并用白细胞介素2进行长期培养。FcεR⁺ T细胞系的上清液可增强变应性鼻炎患者来源的B细胞中IgE的合成，但不能增强IgG的合成。然而，非特应性供体的B细胞中未诱导出IgE合成。IgE增强因子与IgE-琼脂糖凝胶结合，但不与IgG-琼脂糖凝胶结合。这些IgE结合因子的靶B细胞似乎是预先激活的携带IgE的B细胞。
