Frank M M
Int Arch Allergy Appl Immunol. 1985;77(1-2):89-95. doi: 10.1159/000233759.
The last few years have seen rapid advances in our understanding of immune phenomena, and these are now being translated into a new understanding of immunopathology. This paper reviews a number of areas where important new knowledge has been gained in the area of complement and immune complexes as a cause of disease. An understanding of the role of the metabolism of complement proteins has led to an understanding of how these proteins interact with receptors to cause phagocytosis. New understanding of the lysis-producing steps has led to new diagnostic tests for complement-induced damage as well as new knowledge of how complement functions to kill microorganisms. New methods for purifying anaphylatoxins have made these proteins available for study in man. A model of serum sickness in man has allowed for the more detailed understanding of how immune complexes cause disease and has led to the appreciation of new clinical signs of immune-complex-mediated disease in man.
在过去几年里，我们对免疫现象的理解取得了迅速进展，如今这些进展正转化为对免疫病理学的新认识。本文回顾了在补体和免疫复合物作为疾病病因这一领域取得重要新知识的若干方面。对补体蛋白代谢作用的理解，使人们明白这些蛋白如何与受体相互作用以引发吞噬作用。对产生溶解作用步骤的新认识，带来了针对补体诱导损伤的新诊断测试，以及对补体杀灭微生物功能的新知识。纯化过敏毒素的新方法使这些蛋白可用于人体研究。人类血清病模型有助于更详细地了解免疫复合物如何引发疾病，并使人们认识到人类免疫复合物介导疾病的新临床症状。
