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老年急性髓系白血病患者的异基因干细胞移植

[Allogeneic stem cell transplantation in elderly patients with acute myeloid leukemia].

作者信息

Kobayashi Sumiko

机构信息

Tokyo Metropolitan Gerontology Hospital and Institute of Gerontology, Hematology/Transfusion and Cell Therapy.

出版信息

Rinsho Ketsueki. 2019;60(9):1120-1130. doi: 10.11406/rinketsu.60.1120.

Abstract

Acute myeloid leukemia is a disease that mainly affects older populations, with a median age at diagnosis of 67 years, and outcomes for these patients are poor. Reduced-intensity regimen improves survival after allogeneic hematopoietic cell transplantation (HCT), but this has not been well studied. To reduce non-relapse mortality (NRM) among the elderly, geriatric assessment, HCT-Comorbidity index, and disease risk must be studied before HCT.

摘要

急性髓系白血病是一种主要影响老年人群的疾病,诊断时的中位年龄为67岁,这些患者的预后较差。降低强度的方案可改善异基因造血细胞移植(HCT)后的生存率,但对此尚未进行充分研究。为降低老年人的非复发死亡率(NRM),必须在HCT前对老年评估、HCT合并症指数和疾病风险进行研究。

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