Fujii Nobuharu
Division of Blood Transfusion, Okayama University Hospital.
Rinsho Ketsueki. 2019;60(9):1378-1385. doi: 10.11406/rinketsu.60.1378.
The frequency of hematological malignancies is quite high in children, adolescents and young adults. Infertility after treatment is an important issue affecting the quality of life of long-term survivorsas the outcome of treatment is improved. Recently, several guidelines for infertility and fertility preservation have been published. Consequently, it has become easier to obtain information on the risk of infertility and fertility preservation therapy for each treatment. However, the information on the optimal timing for fertility preservation and current outcomes of assisted reproductive technology using stored oocytes, embryos, ovarian tissues, or sperm remains limited. Further, whether fertility preservation while using a new drug with unknown risk for infertility should be performed remains an unresolved issue.
血液系统恶性肿瘤在儿童、青少年和青年中的发病率相当高。随着治疗效果的改善,治疗后的不孕问题成为影响长期幸存者生活质量的一个重要问题。最近,已经发布了几份关于不孕和生育力保存的指南。因此,获取每种治疗方法导致不孕的风险和生育力保存治疗信息变得更加容易。然而,关于生育力保存的最佳时机以及使用冷冻卵母细胞、胚胎、卵巢组织或精子的辅助生殖技术目前的结果的信息仍然有限。此外,在使用一种对不孕风险未知的新药时是否应该进行生育力保存仍是一个未解决的问题。