由脯氨酸和哌啶酸衍生物温和合成双环烷氧基恶唑鎓盐
A Mild Synthesis of Bicyclic Alkoxyoxazolium Salts from Proline and Pipecolic Acid Derivatives.
作者信息
Spinozzi Eleonora, Bauer Adriano, Maulide Nuno
机构信息
Institute of Organic Chemistry University of Vienna Währinger Straße 38 1090 Vienna Austria.
出版信息
European J Org Chem. 2019 Sep 1;2019(31-32):5230-5233. doi: 10.1002/ejoc.201900985. Epub 2019 Aug 8.
Abstract
A regio- and chemoselective preparation of bicyclic alkoxyoxazolium salts from amide derivatives of proline and pipecolic acid by electrophilic amide activation is reported. Mechanistic NMR experiments suggest an unusual role for the base and highlight the effect of substitution pattern of the substrates.
摘要
报道了通过亲电酰胺活化从脯氨酸和哌啶酸的酰胺衍生物区域选择性和化学选择性制备双环烷氧基恶唑鎓盐。机理NMR实验表明碱具有不同寻常的作用，并突出了底物取代模式的影响。
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