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1
Hydroxycarbamide and white matter integrity in pediatric sickle cell disease: Commentary to accompany: Hydroxycarbamide treatment in children with sickle cell anaemia is associated with more intact white matter integrity: a quantitative MRI study.羟基脲与小儿镰状细胞病中的白质完整性：随附评论：镰状细胞贫血患儿的羟基脲治疗与更完整的白质完整性相关：一项定量MRI研究
Br J Haematol. 2019 Oct;187(2):141-143. doi: 10.1111/bjh.16252.
2
Hydroxycarbamide treatment in children with Sickle Cell Anaemia is associated with more intact white matter integrity: a quantitative MRI study.羟基脲治疗镰状细胞贫血症儿童与更完整的白质完整性相关：一项定量 MRI 研究。
Br J Haematol. 2019 Oct;187(2):238-245. doi: 10.1111/bjh.16063. Epub 2019 Jun 18.
3
Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial.羟基脲与慢性输血用于维持镰状细胞贫血患儿经颅多普勒血流速度的比较——输血转换为羟基脲的经颅多普勒研究（TWiTCH）：一项多中心、开放标签、3期、非劣效性试验。
Lancet. 2016 Feb 13;387(10019):661-670. doi: 10.1016/S0140-6736(15)01041-7. Epub 2015 Dec 6.
4
Hydroxycarbamide treatment reduces transcranial Doppler velocity in the absence of transfusion support in children with sickle cell anaemia, elevated transcranial Doppler velocity, and cerebral vasculopathy: the EXTEND trial.羟基脲治疗可降低镰状细胞贫血伴高颅超声多普勒速度和脑血管病儿童的经颅超声多普勒速度，而无需输血支持：EXTEND 试验。
Br J Haematol. 2021 Nov;195(4):612-620. doi: 10.1111/bjh.17698. Epub 2021 Jul 22.
5
Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG).儿童期镰状细胞贫血羟脲治疗的多中心随机对照试验（BABY HUG）。
Lancet. 2011 May 14;377(9778):1663-72. doi: 10.1016/S0140-6736(11)60355-3.
6
Hydroxycarbamide in children with sickle cell anaemia after first-dose vs. chronic therapy: pharmacokinetics and predictive models for drug exposure.羟基脲治疗镰状细胞贫血儿童：首剂量与慢性治疗的药代动力学及药物暴露预测模型。
Br J Clin Pharmacol. 2018 Jul;84(7):1478-1485. doi: 10.1111/bcp.13426. Epub 2017 Nov 28.
7
Low-dose hydroxycarbamide therapy may offer similar benefit as maximum tolerated dose for children and young adults with sickle cell disease in low-middle-income settings.在中低收入环境下，低剂量羟基脲疗法对于患有镰状细胞病的儿童和年轻人可能与最大耐受剂量疗法具有相似的疗效。
F1000Res. 2018 Sep 4;7. doi: 10.12688/f1000research.14589.1. eCollection 2018.
8
Hydroxycarbamide treatment and brain MRI/MRA findings in children with sickle cell anaemia.镰状细胞贫血患儿的羟基脲治疗及脑部MRI/MRA检查结果
Br J Haematol. 2016 Oct;175(2):331-338. doi: 10.1111/bjh.14235. Epub 2016 Sep 8.
9
Treating sickle cell anaemia with hydroxycarbamide.用羟基脲治疗镰状细胞贫血。
Br J Haematol. 2014 Jan;164(2):296-7. doi: 10.1111/bjh.12600. Epub 2013 Oct 5.
10
Chromosome damage and repair in children with sickle cell anaemia and long-term hydroxycarbamide exposure.长期羟基脲暴露的镰状细胞贫血儿童的染色体损伤与修复。
Br J Haematol. 2011 Jul;154(1):134-40. doi: 10.1111/j.1365-2141.2011.08698.x. Epub 2011 May 4.

本文引用的文献

1
Hydroxycarbamide treatment in children with Sickle Cell Anaemia is associated with more intact white matter integrity: a quantitative MRI study.羟基脲治疗镰状细胞贫血症儿童与更完整的白质完整性相关：一项定量 MRI 研究。
Br J Haematol. 2019 Oct;187(2):238-245. doi: 10.1111/bjh.16063. Epub 2019 Jun 18.
2
Hydroxyurea reduces cerebral metabolic stress in patients with sickle cell anemia.羟基脲可降低镰状细胞贫血患者的大脑代谢应激。
Blood. 2019 May 30;133(22):2436-2444. doi: 10.1182/blood-2018-09-876318. Epub 2019 Mar 11.
3
White matter integrity and processing speed in sickle cell anemia.镰状细胞贫血症的脑白质完整性和处理速度。
Neurology. 2018 Jun 5;90(23):e2042-e2050. doi: 10.1212/WNL.0000000000005644. Epub 2018 May 11.
4
PRIMARY STROKE PREVENTION IN CHILDREN WITH SICKLE CELL ANEMIA LIVING IN AFRICA: THE FALSE CHOICE BETWEEN PATIENT-ORIENTED RESEARCH AND HUMANITARIAN SERVICE.生活在非洲的镰状细胞贫血患儿的原发性中风预防：以患者为导向的研究与人道主义服务之间的错误选择。
Trans Am Clin Climatol Assoc. 2016;127:17-33.
5
The severity of anaemia depletes cerebrovascular dilatory reserve in children with sickle cell disease: a quantitative magnetic resonance imaging study.镰状细胞病患儿贫血的严重程度会消耗脑血管扩张储备：一项定量磁共振成像研究。
Br J Haematol. 2017 Jan;176(2):280-287. doi: 10.1111/bjh.14424. Epub 2016 Dec 1.
6
A Novel Imaging Marker for Small Vessel Disease Based on Skeletonization of White Matter Tracts and Diffusion Histograms.一种基于白质束骨架化和弥散直方图的小血管病新成像标志物。
Ann Neurol. 2016 Oct;80(4):581-92. doi: 10.1002/ana.24758. Epub 2016 Aug 29.
7
Reduced cerebrovascular reserve is regionally associated with cortical thickness reductions in children with sickle cell disease.脑血管储备降低与镰状细胞病患儿的皮质厚度区域性减少有关。
Brain Res. 2016 Jul 1;1642:263-269. doi: 10.1016/j.brainres.2016.03.041. Epub 2016 Mar 26.
8
Central nervous system complications and management in sickle cell disease.镰状细胞病的中枢神经系统并发症及处理。
Blood. 2016 Feb 18;127(7):829-38. doi: 10.1182/blood-2015-09-618579. Epub 2016 Jan 12.
9
Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial.羟基脲与慢性输血用于维持镰状细胞贫血患儿经颅多普勒血流速度的比较——输血转换为羟基脲的经颅多普勒研究（TWiTCH）：一项多中心、开放标签、3期、非劣效性试验。
Lancet. 2016 Feb 13;387(10019):661-670. doi: 10.1016/S0140-6736(15)01041-7. Epub 2015 Dec 6.
10
Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members.镰状细胞病的管理：专家小组成员 2014 年循证报告的总结。
JAMA. 2014 Sep 10;312(10):1033-48. doi: 10.1001/jama.2014.10517.

Hydroxycarbamide and white matter integrity in pediatric sickle cell disease: Commentary to accompany: Hydroxycarbamide treatment in children with sickle cell anaemia is associated with more intact white matter integrity: a quantitative MRI study.

作者信息

Lance Eboni I, Jordan Lori C

机构信息

Department of Neurodevelopmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA.

Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

出版信息

Br J Haematol. 2019 Oct;187(2):141-143. doi: 10.1111/bjh.16252.

DOI:10.1111/bjh.16252
PMID:31598967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6800718/
Abstract
摘要