Department of Histocompatibility, Amiens University Medical Center, Amiens, France.
EA 4666 HEMATIM, Jules Verne University of Picardie, Amiens, France.
Int J Immunogenet. 2020 Feb;47(1):65-66. doi: 10.1111/iji.12457. Epub 2019 Oct 9.
We report a discordance between complement-dependent cytotoxicity and next-generation sequencing molecular typing revealing HLA-B15:47:01 allele with undefined serological equivalent confirmed by high-level immunization against the B15 serotype. Due to the high-level immunization against HLA-B15 and B70 antigens, we considered the HLA-B15:47:01 allele to be B Blank and not as B15 or B70 serological specificity.
我们报告了补体依赖性细胞毒性与下一代测序分子分型之间的不一致,该分型揭示了 HLA-B15:47:01 等位基因,其血清学等效物无法确定,通过对 B15 亚型的高水平免疫得到确认。由于针对 HLA-B15 和 B70 抗原的高水平免疫,我们认为 HLA-B15:47:01 等位基因是 B 空白,而不是 B15 或 B70 的血清学特异性。