Ranjan R, Adhikary D, Rahman M, Mandal S, Saha S K, Adhikary A B
Dr Redoy Ranjan, Assistant Professor, Department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh; E-mail:
Mymensingh Med J. 2019 Oct;28(4):811-818.
This study aimed to evaluate myocardial protective effect of isoflurane and propofol as a fast tract anesthesia in off pump coronary artery bypass graft surgery by measuring postoperative cardiac enzyme Troponin-I, and liver enzyme. The study was conducted on 260 patients scheduled to undergo elective off pump coronary artery bypass graft surgery. Patients were randomly allocated to receive either isoflurane or propofol anesthesia and was aimed to extubated within 6 hours. Troponin-I levels were measured preoperatively, at arrival in postoperative intensive care unit, at 12, 24, 48, 72 hours and 4 weeks following surgery. Liver function was also assessed and compared between preoperative and postoperative values. There is no difference in Troponin-I levels between the two studies groups at observed pre and post-operative time intervals. Fast tract anesthesia using isoflurane and propofol provides same myocardial protection during and after OPCABG and overall outcome was excellent.
本研究旨在通过测量术后心肌酶肌钙蛋白I和肝酶，评估异氟烷和丙泊酚作为非体外循环冠状动脉搭桥手术快速通道麻醉时的心肌保护作用。该研究对260例计划接受择期非体外循环冠状动脉搭桥手术的患者进行。患者被随机分配接受异氟烷或丙泊酚麻醉，并计划在6小时内拔管。术前、术后重症监护病房入院时、术后12、24、48、72小时及4周测量肌钙蛋白I水平。还评估并比较术前和术后的肝功能值。在观察到的术前和术后时间间隔内，两个研究组的肌钙蛋白I水平没有差异。使用异氟烷和丙泊酚的快速通道麻醉在非体外循环冠状动脉搭桥手术期间和术后提供相同的心肌保护，总体结果良好。
