Department of Epidemiology & Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, PR China.
Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, PR China.
Biomark Med. 2019 Nov;13(16):1417-1427. doi: 10.2217/bmm-2019-0161. Epub 2019 Oct 10.
An existing meta-analysis have investigated the PTX3 levels in systemic lupus erythematosus (SLE) patients, but the number of studies has increased since 2015. We performed an updated meta-analysis to derive a more accurate estimation. The related literature was systematically searched in PubMed, Embase and The Cochrane Library database (up to 28 February, 2019). SLE patients had significantly higher PTX3 levels than controls (pooled SMD = 0.48; 95% CI: 0.11-0.84). Subgroup analyses indicated SLE patients from non-Caucasian population, with age ≥45 years, SLE disease activity index (SLEDAI) ≥10 and plasma samples had higher PTX3 levels. Circulating PTX3 levels are increased in SLE patients, and affected by age, ethnicity, SLEDAI and sample type.
一项现有的荟萃分析已经研究了系统性红斑狼疮（SLE）患者的 PTX3 水平，但自 2015 年以来，相关研究数量有所增加。我们进行了一项更新的荟萃分析，以得出更准确的估计。系统地检索了 PubMed、Embase 和 The Cochrane Library 数据库（截至 2019 年 2 月 28 日）中的相关文献。SLE 患者的 PTX3 水平明显高于对照组（合并 SMD=0.48；95%CI：0.11-0.84）。亚组分析表明，来自非白种人群、年龄≥45 岁、SLE 疾病活动指数（SLEDAI）≥10 以及使用血浆样本的 SLE 患者 PTX3 水平更高。循环 PTX3 水平在 SLE 患者中升高，并受年龄、种族、SLEDAI 和样本类型的影响。
