Jiang H, Shi M Y, Yao L R
Sci Sin B. 1985 Apr;28(4):365-72.
Using a method from Billingham, an animal model of the neonatal allotransplantation tolerance of SWI to C57BL inbred mice was established and the mechanism of neonatal tolerance established by us was preliminarily studied. Our experiment indicates that the clonal deletion theory is not the unique explanation for the neonatal tolerance and a peripheral active inhibitory mechanism including suppressor cells may participate in mediating and maintaining the neonatal tolerance. The suppressor cells in the neonatal tolerance are radioresistant, but rather sensitive to mitomycin C treatment. These results suggest that suppressor cell population may be nonhomogenous. Further studies about this problem are needed.
采用比林厄姆的方法，建立了SWI对C57BL近交系小鼠新生同种异体移植耐受的动物模型，并对我们建立的新生耐受机制进行了初步研究。我们的实验表明，克隆清除理论并非新生耐受的唯一解释，一种包括抑制细胞的外周主动抑制机制可能参与介导和维持新生耐受。新生耐受中的抑制细胞对辐射有抗性，但对丝裂霉素C处理敏感。这些结果表明，抑制细胞群体可能是非同质性的。对此问题还需要进一步研究。
