Fray A, Burtin C, Scheinmann P, Lespinats G, Canu P
Agents Actions. 1985 Apr;16(3-4):284-6. doi: 10.1007/BF01983161.
Dimaprit, a histamine H2-receptor agonist, injected daily i.p. to fibrosarcoma-bearing mice, induced a decrease in tumour growth and an increase in survival. Dimaprit, added to tumour cell cultures (10(-4) M), inhibited the incorporation of 3H-thymidine while embryonic cell cultures were unaffected. This particular anti-tumour activity is probably H2-independent as histamine and impromidine have no effect on tumour cell cultures.
二甲双胍，一种组胺H2受体激动剂，每天腹腔注射给携带纤维肉瘤的小鼠，可导致肿瘤生长减缓并延长生存期。将二甲双胍添加到肿瘤细胞培养物中（10⁻⁴ M），可抑制3H-胸腺嘧啶核苷的掺入，而对胚胎细胞培养物无影响。这种特殊的抗肿瘤活性可能与H2无关，因为组胺和英普咪定对肿瘤细胞培养物没有影响。
