Kato S, Ishii H, Kano S, Hagihara S, Todoroki T, Nagata S, Takahashi H, Shigeta Y, Tsuchiya M
Alcohol. 1985 Jan-Feb;2(1):35-8. doi: 10.1016/0741-8329(85)90011-4.
To determine whether serum alcohol dehydrogenase (ADH) activity reflects hepatic damage of centrilobular region (zone 3), the rats were given either bromobenzene (BB) or allyl alcohol (AA) IP to produce the pericen tral or periportal necrosis respectively. After AA or BB serum alanine aminotransferase (ALT) activity showed no significant difference between the two groups. By contrast, serum ADH and glutamate dehydrogenase (GLDH) activities were elevated preferentially in the BB treated rats. However, AA administration to rats also resulted in a significant increase in GLDH activity, whereas ADH activity was only slightly elevated when compared to controls. Moreover, acute ethanol administration to rats resulted in a significant elevation of the serum ADH activity, whereas serum GLDH and ALT activities remained normal. These data suggest that serum ADH activity appears to be a sensitive and specific marker of hepatic centrilobular damage.
为了确定血清乙醇脱氢酶（ADH）活性是否反映小叶中央区（3区）的肝损伤，给大鼠腹腔注射溴苯（BB）或烯丙醇（AA），分别造成小叶中央或门周坏死。给予AA或BB后，两组之间血清丙氨酸转氨酶（ALT）活性无显著差异。相比之下，血清ADH和谷氨酸脱氢酶（GLDH）活性在BB处理的大鼠中优先升高。然而，给大鼠施用AA也导致GLDH活性显著增加，而与对照组相比，ADH活性仅略有升高。此外，给大鼠急性注射乙醇导致血清ADH活性显著升高，而血清GLDH和ALT活性保持正常。这些数据表明，血清ADH活性似乎是肝小叶中央损伤的敏感和特异性标志物。
