Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University Medical Faculty, Sıhhiye, Ankara, Turkey, Tel.: +90 5464750175.
Division of Critical Care, Department of Anaesthesiology and Reanimation, Hacettepe University Medical Faculty, Ankara, Turkey.
J Perinat Med. 2019 Nov 26;47(9):947-957. doi: 10.1515/jpm-2019-0125.
Objective To evaluate the characteristics of obstetric admissions to an intensive care unit (ICU) and assess the utility of Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA) and the Glasgow Coma Scale (GCS). Methods This study is consisted of 160 patients admitted to an ICU during the antenatal period or within 7 days at the postpartum period. Clinical characteristics and ICU scores were evaluated. Results The rate of admission to the ICU was 7.8/1000 deliveries. Four cases ended with maternal mortality (2.5%). The most common hospitalization indications were hypertensive disorders of pregnancy, cardiovascular disorders and obstetric hemorrhage, at 40 (25%), 34 (21.2%), and 31 (19.3%) cases, respectively. The receiver operating characteristics (ROC) curve analysis for prediction of maternal mortality revealed area under curve (AUC) values as 0.971 both for APACHE II and predicted mortality rate (PMR), and 24.5 and 47.1 were determined as the cut-offs with sensitivities of 100%. AUCs were also 0.901 and 0.929 for the initial and worst SOFA score, respectively. The cut-off value for the initial and worst SOFA score was 3.5, with a sensitivity of 100%, and was 10 with a specificity of 98.9%, respectively. Conclusion APACHE II and PMR overpredict maternal mortality, but those higher scores predict maternal mortality. Higher SOFA scores are related with maternal mortalities with high specificity.
目的 评估产科患者入住重症监护病房(ICU)的特征,并评估急性生理学与慢性健康评估 II 评分(APACHE II)、序贯器官衰竭评估(SOFA)和格拉斯哥昏迷评分(GCS)的效用。方法 本研究纳入了 160 例在产前或产后 7 天内入住 ICU 的患者。评估了临床特征和 ICU 评分。结果 ICU 入住率为 7.8/1000 分娩。4 例患者死亡(2.5%)。最常见的住院指征是妊娠高血压疾病、心血管疾病和产科出血,分别为 40 例(25%)、34 例(21.2%)和 31 例(19.3%)。预测产妇死亡率的受试者工作特征(ROC)曲线分析显示,APACHE II 和预测死亡率(PMR)的曲线下面积(AUC)值分别为 0.971,确定 24.5 和 47.1 为截断值,敏感性均为 100%。初始和最差 SOFA 评分的 AUC 值分别为 0.901 和 0.929。初始和最差 SOFA 评分的截断值分别为 3.5,敏感性为 100%,特异性为 98.9%,截取值为 10。结论 APACHE II 和 PMR 过高预测产妇死亡率,但评分越高,预测死亡率越高。更高的 SOFA 评分与产妇死亡率相关,特异性高。