Al-Bachaji Imman Naji, Al-Buhadiliy Ali Kadhem, Al-Kuraishy Hayder Mutter, Al-Gareeb Ali Ismail
Department of Clinical Pharmacology, Medicine and Therapeutic, Al- Mustansiriya University, Baghdad, Iraq.
J Pak Med Assoc. 2019 Aug;69(Suppl 3)(8):S31-S35.
To evaluate the effect of proton pump inhibitors on glycaemic indices in patients with type 2 diabetes mellitus.
The case-control study was conducted at the National Diabetes Centre, Mustansiriyah University, Baghdad, Iraq, from January to April 2018, and comprised type 2 diabetes patients and non-diabetic healthy controls. The subjects were divided into three groups: Group A had controls on proton pump inhibitors; Group B had patients treated with metformin 850 g/day; and Group C had patients treated with metformin 850 g/day plus proton pump inhibitors. Gastrin serum levels, lipid profile, glycaemic indices and blood pressure changes were measured in the groups. Data was analysed using SPSS 20.
Of the 100 subjects, 60(60%) were patients with a mean age of 54.98}4.22 years, while40(40%) were controls with a mean age of 50.69}4.34 years. Group A had 40(40%) subjects, while Group B and Group C had 30(30%) each. Proton pump inhibitors improved glycaemic indices and lipid profile in the patients 9p<0.05) while increasing gastrin serum levels which were significantly correlated with reduction in glycated haemoglobin, fasting blood glucose and augmentation of β-cell function (p<0.05 each).
Proton pump inhibitors improved glycemic indices and metabolic profile in type 2 diabetes patients via augmentation of gastrin serum levels.
评估质子泵抑制剂对2型糖尿病患者血糖指标的影响。
该病例对照研究于2018年1月至4月在伊拉克巴格达穆斯坦西里亚大学国家糖尿病中心进行，纳入2型糖尿病患者和非糖尿病健康对照者。受试者分为三组：A组为服用质子泵抑制剂的对照者；B组为接受每日850毫克二甲双胍治疗的患者；C组为接受每日850毫克二甲双胍加质子泵抑制剂治疗的患者。测量各组的胃泌素血清水平、血脂谱、血糖指标和血压变化。使用SPSS 20软件进行数据分析。
100名受试者中，60名（60%）为患者，平均年龄为54.98±4.22岁，40名（40%）为对照者，平均年龄为50.69±4.34岁。A组有40名（40%）受试者，B组和C组各有30名（30%）。质子泵抑制剂改善了患者的血糖指标和血脂谱（p<0.05），同时提高了胃泌素血清水平，胃泌素血清水平与糖化血红蛋白降低、空腹血糖降低及β细胞功能增强显著相关（均p<0.05）。
质子泵抑制剂通过提高胃泌素血清水平改善2型糖尿病患者的血糖指标和代谢状况。
