Rasheed Huda Abdulbaki, Al-Kuraishy Hayder M, Al-Gareeb Ali Ismail
Department of Clinical Pharmacology, Medicine and Therapeutic, Al- Mustansiriya University, Baghdad, Iraq.
J Pak Med Assoc. 2019 Aug;69(Suppl 3)(8):S98-S102.
To assess the reno-protective effect of rosuvastatin on gentamicin-induced nephrotoxicity in rats.
The prospective experimental study was conducted at the College of Medicine, Mustansiriya University, Baghdad, Iraq, from March to July, 2018, and comprised Sprague Dawley male rats aged 3-4 months and weighing 200-400g each. The rats were divided into 3 equal groups which were treated for 14 days. Group1 was treated with distilled water plus normal saline, Group2 with distilled water plus gentamicin, and Group3 with rosuvastatin plus gentamicin. Parameters measured were blood urea, serum creatinine, serum malondialdehyde, superoxide dismutase, glutathione reductase, neutrophil gelatinase associated lipocalin, kidney injury molecule-1, interleukin- 18 and Cystatin-c. SPSS 20 was used for data analysis.
Of the 30 rats, there were 10(33.3%) in each of the three groups. Rosuvastatin produced significant renoprotective effect through reduction of blood urea, kidney injury molecule-1 and interleukin-18 (p<0.01) compared to the gentamicin group.
Rosuvastatin was found to be a reno-protective against gentamicin-induced nephrotoxicity through modulation of pro-inflammatory and oxidative/anti-oxidant pathways.
评估瑞舒伐他汀对庆大霉素诱导的大鼠肾毒性的肾脏保护作用。
前瞻性实验研究于2018年3月至7月在伊拉克巴格达穆斯坦西里亚大学医学院进行，实验对象为3至4个月大、体重200 - 400克的雄性Sprague Dawley大鼠。将大鼠分为3组，每组数量相等，均接受为期14天的治疗。第1组用蒸馏水加生理盐水治疗，第2组用蒸馏水加庆大霉素治疗，第3组用瑞舒伐他汀加庆大霉素治疗。测量的参数包括血尿素、血清肌酐、血清丙二醛、超氧化物歧化酶、谷胱甘肽还原酶、中性粒细胞明胶酶相关脂质运载蛋白、肾损伤分子-1、白细胞介素-18和胱抑素-C。采用SPSS 20进行数据分析。
30只大鼠中，三组各有10只（33.3%）。与庆大霉素组相比，瑞舒伐他汀通过降低血尿素、肾损伤分子-1和白细胞介素-18产生了显著的肾脏保护作用（p<0.01）。
发现瑞舒伐他汀通过调节促炎和氧化/抗氧化途径对庆大霉素诱导的肾毒性具有肾脏保护作用。
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